The Syrén lab is exploring both sequence- and structural- based protein engineering methods to enable generation of biocatalysts with improved catalytic versatilities. Besides reshaping of the active site, we are interested in rational redesign of enzyme and solvent dynamics for altered catalytic function, using terpene cyclases as model systems.
Life is easy to identify, but remarkably hard to define. One fundamental property of living organisms is the order they create in their environment through evolved metabolic pathways, organized structures and self-replication which are basal energy-consuming processes dependent on enzymes that accelerate the chemistry of life up to 10^26-fold. Fundamental and organizational tasks, for instance energy conversion and information processing, would take millions – or even billions – of years in the absence of enzymes, thus representing timescales that would be incompatible with life.
The Syrén lab works with computer simulations and bioinformatics, as well as experimental biotechnology and protein engineering to enhance our fundamental understanding of enzymes, their mechanisms and evolution at the atomistic level. Towards reaching this goal we bridge fundamental chemical principles with state-of-the art biotechnology. Through transdisciplinary scientific methods we are developing novel enzyme engineering strategies for applications within biopolymer science and for the generation of superior biopharmaceuticals and fine chemicals from renewable sources.