chembiochem cover

Peer-reviewed articles:

* = Paper as corresponding author

# = Shared first authorship

  1. A. Eriksson, C. Kürten, P.-O. Syrén*, Protonation-initiated cyclization by a class II terpene cyclase assisted by tunneling. ChemBioChem 2017, 18, 2301-2305.
  1. A. Eriksson, C. Kürten, P.-O. Syrén*, Cover Feature: Protonation-initiated cyclization by a class II terpene cyclase assisted by tunneling. ChemBioChem 2017, 18, 2293.
  1. J. Fagerland, D. Pappalardo, B. Schmidt, P.-O. Syrén, A. F. Wistrand, Template assisted enzymatic synthesis of oligopeptides from a polylactide chain. Biomacromolecules, 2017, 18, 4271−4280.
  1. C. Gustafsson, S. Vassiliev, C. Kürten, P.-O. Syrén, T. Brinck. MD Simulations Reveal Complex Water Paths in Squalene–Hopene Cyclase: Tunnel-Obstructing Mutations Increase the Flow of Water in the Active Site. ACS Omega 2017, 2, 8495−8506.
  1. J. Fink, P.-O. Syrén*, Redesign of water networks for efficient biocatalysis. Curr. Opin. Chem. Biol. 2017, 37, 107-114.
  1. S. C. Hammer, P.-O. Syrén#, B. Hauer. Substrate Pre-Folding and Water Molecule Organization Matters for Terpene Cyclase Catalyzed Conversion of Unnatural Substrates. ChemistrySelect, 2016, 1, 3589–3593.
  1. P-O. Syrén, S. Henche, A. Eichler, B. Nestl, B. Hauer. Squalene-hopene cyclases – evolution, dynamics and catalytic scope. Curr. Opin. Struct. Biol. 2016, 41, 73-82.
  1.  Special issue: Enzyme catalysis. C. Kürten, B. Carlberg, P.-O. Syrén*. Mechanism-guided discovery of an esterase scaffold with promiscuous amidase activity. Catalysts, 2016, 6, 90.
  1. C. Kürten, P.-O. Syrén*. Unraveling entropic rate acceleration induced by solvent dynamics in membrane enzymes. J. Vis. Exp. 2016, 107, e53168, doi:10.3791/53168.
  1. C. Kürten, M. Uhlén, P.-O. Syrén*. Overexpression of functional human oxidosqualene cyclase in Escherichia coli. Protein Express Purif, 2015, 115, 46-53.
  1. Featured on the cover of Chemical Communications: P. Hendil-Forssell, M. Martinell, P.-O. Syrén*. Exploring water as building bricks in enzyme engineering. Chem. Commun. 2015, 51, 17221-17224.
  1. P-O. Syrén*, S.C. Hammer, B. Claasen, B. Hauer. Entropy is Key to the Formation of Pentacyclic Terpenoids by Enzyme-Catalyzed Polycyclization. Angew. Chem. Int. Ed. 2014, 126, 4945-4949.
  1. P-O. Syrén*, The solution to nitrogen inversion in amidases. FEBS J 2013, 280, 3069-3083.
  1. M. Seitz, P.-O. Syrén, L. Steiner, J. Klebensberger, B. Nestl, B. Hauer, Synthesis of heterocyclic terpenoids by promiscuous squalene-hopene cyclases. ChemBioChem 2013, 14, 436-439.
  1. S. C. Hammer#, P.-O. Syrén#, M. Seitz, B. Nestl, B. Hauer, Squalene hopene cyclases: highly promiscuous and evolvable catalysts for stereoselective C-C and C-X bond formation. Curr. Opin. Chem. Biol. 2013, 17, 293-300.
  1. P-O. Syrén*, F. Le Joubioux, Y. Ben Henda, T. Maugard, K. Hult, M. Graber, Proton shuttle mechanism in the transition state of lipase catalyzed N-acylation of amino alcohols. ChemCatChem 2013, 5, 1842-1853.
  1. S. C. Hammer, J. Dominicus, P.-O. Syrén, B. Nestl, B. Hauer, Stereoselective Friedel–Crafts alkylation catalyzed by squalene hopene cyclases. Tetrahedron, 2012, 68, 7624-7629.
  1. P-O. Syrén, P. Hendil-Forssell, L. Aumailley, W. Besenmatter, F. Gounine, A. Svendsen, M. Martinelle, K. Hult, Esterases with an introduced amidase-like hydrogen bond in transition state display increased amidase specificity. ChemBioChem 2012, 13, 645–648.
  1. P-O. Syrén, K. Hult, Amidases have a hydrogen bond that facilitates nitrogen inversion but esterases have not. ChemCatChem 2011, 3, 853-860.
  1. K. Engström, M. Vallin, P.-O. Syrén, K. Hult, J.-E. Bäckvall, Mutated variant of Candida antarctica lipase B in (S)-selective dynamic kinetic resolution of secondary alcohols. Org. Biomol. Chem. 2011, 9, 81-82.
  1. P-O. Syrén, K. Hult, Substrate Conformations Set the Rate of Enzymatic Acrylation by Lipases. ChemBioChem 2010, 11, 802 – 810.
  1. S. Marton, V. Léonard-Nevers, P.-O. Syrén, C. Bauer, S. Lamare, K. Hult, V. Tranc, M. Graber, Mutations in the stereospecificity pocket and at the entrance of the active site of Candida antarctica lipase B enhancing enzyme enantioselectivity. J. Mol. Catal. B: Enzym. 2010, 65, 11-17.
  1. P.-O. Syrén, E. Lindgren, H. W. Hoeffken, C. Branneby, S. Maurer, B. Hauer, K. Hult, Increased activity of enzymatic transacylation of acrylates through rational design of lipases. J. Mol. Catal. B: Enzym. 2010, 65, 3-10.
  1. M. Vallin, P.-O. Syrén, K. Hult, Mutant Lipase-Catalyzed Kinetic Resolution of Bulky Phenyl Alkyl sec-Alcohols: A Thermodynamic Analysis of Enantioselectivity. ChemBioChem 2010, 11, 411-416.
  1. P.-O. Syrén, A. Rozkov, S. R. Schmidt, P. Strömberg, Milligram scale parallel purification of plasmid DNA using anion-exchange membrane capsules and a multi-channel peristaltic pump. J. Chromatogr. B 2007, 856, 68-74.

Book chapters:

  1. I. V. Pavlidis, N.M. Hendrikse, P.-O. Syrén*, Computational techniques for efficient biocatalysis. Royal Society of Chemistry. 2017, accepted.
  1. P.-O. Syrén, Understanding esterase and amidase reaction specificities by molecular modelling. Understanding enzymes; Function, Design, Engineering and Analysis. 2016 (PanStandford Publishing).

 Conference proceedings:

  1. N. M. Hendrikse, P. Stromberg, E. Nordling, P.-O. Syrén*, Redesign of biosynthetic enzymes using ancestral sequence reconstruction. FEBS J. 2017, 284, 86-87.
  1. Biundo, D Ribitsch, P.-O. Syrén, GM Guebitz. Increasing amide acceptance on a polyester-hydrolyzing enzyme. New Biotechnology, 2016, S105.


  1. Å. Östlund, P.-O. Syrén, C. Jönsson, D. Ribitsch, M. Syrén. Re: Mix–Separation and recycling of textile waste fiber blends.