chembiochem cover


  1. W. Farhat, A. Biundo, A. Stamm, E. Malmström, P.-O. Syrén*. Lactone monomers obtained by enzyme catalysis and their use in reversible thermoresponsive networks. J. Appl. Polym. Sci. 2019, accepted.TOC manuscript 32

  2. Biundo, R. Subagia, M. Maurer, D. Ribitsch, P.-O. Syrén*, G. M. Guebitz. Switched reaction specificity in polyesterases towards amide bond hydrolysis by enzyme engineering. RSC Adv. 2019, 9, 36217-36226.Water design Figure 2C

  3. Special issue on emerging future research leaders: Stamm, A. Biundo, B. Schmidt, J. Brücher, S. Lundmark, P. Olsén, L. Fogelström, E. Malmström, U. T. Bornscheuer,    P.-O. Syrén* A retrobiosynthesis-based route to generate pinene-derived polyesters. ChemBioChem 2019, 20, 1664-1671.Stamm et al 2019 TOC

  4. Special issue on Chemo-enzymatic cascade reactions: Farhat, A. Stamm, M. Robert-Monpate, A. Biundo, P.-O. Syrén*. Biocatalysis for terpene-based polymers. Z. Naturforsch. C. 2019, 74, 91–100.TOC Farhat et al 2019

  5. A. Stamm, M. Tengdelius, B. Schmidt, J. Engström, P. O. Syrén, L. Fogelström, E. Malmström. Chemo-enzymatic pathways toward pinene-based renewable materials. Green Chem. 2019, 21, 2720–2731.TOC Stamm et al Green Chem 2019


  6. M. Hendrikse, G. Charpentier, E. Nordling, P.-O. Syrén*, Ancestral diterpene cyclases show increased thermostability and substrate acceptance. FEBS J 2018, 285 4660–4673.Hendrikse et al 2018 TOC

  7. Elected among the top 25 papers in JOC during 2018

    Featured on the cover of J. Org. Chem:

    P.-O. Syrén*, Enzymatic hydrolysis of tertiary amide bonds by anti nucleophilic attack and protonation. J. Org. Chem. 2018, 83, 13543–13548.TOC Syrén 2018


  8. A. Eriksson, C. Kürten, P.-O. Syrén*, Protonation-initiated cyclization by a class II terpene cyclase assisted by tunneling. ChemBioChem 2017, 18, 2301-2305.
  9. A. Eriksson, C. Kürten, P.-O. Syrén*, Cover Feature: Protonation-initiated cyclization by a class II terpene cyclase assisted by tunneling. ChemBioChem 2017, 18, 2293.
  10. J. Fagerland, D. Pappalardo, B. Schmidt, P.-O. Syrén, A. F. Wistrand, Template assisted enzymatic synthesis of oligopeptides from a polylactide chain. Biomacromolecules, 2017, 18, 4271−4280.
  11. C. Gustafsson, S. Vassiliev, C. Kürten, P.-O. Syrén, T. Brinck. MD Simulations Reveal Complex Water Paths in Squalene–Hopene Cyclase: Tunnel-Obstructing Mutations Increase the Flow of Water in the Active Site. ACS Omega 2017, 2, 8495−8506.
  12. M. J. Fink, P.-O. Syrén*, Redesign of water networks for efficient biocatalysis. Curr. Opin. Chem. Biol. 2017, 37, 107-114.
  13. S. C. Hammer, P.-O. Syrén#, B. Hauer. Substrate Pre-Folding and Water Molecule Organization Matters for Terpene Cyclase Catalyzed Conversion of Unnatural Substrates. ChemistrySelect, 2016, 1, 3589–3593.
  14. P.-O. Syrén, S. Henche, A. Eichler, B. Nestl, B. Hauer. Squalene-hopene cyclases – evolution, dynamics and catalytic scope. Curr. Opin. Struct. Biol. 2016, 41, 73-82.
  15. Special issue: Enzyme catalysis: C. Kürten, B. Carlberg, P.-O. Syrén*. Mechanism-guided discovery of an esterase scaffold with promiscuous amidase activity. Catalysts, 2016, 6, 90.
  16. C. Kürten, P.-O. Syrén*. Unraveling entropic rate acceleration induced by solvent dynamics in membrane enzymes. J. Vis. Exp. 2016, 107, e53168, doi:10.3791/53168.

    Publications before 2016

  17. C. Kürten, M. Uhlén, P.-O. Syrén*. Overexpression of functional human oxidosqualene cyclase in Escherichia coli. Protein Express Purif, 2015, 115, 46-53.
  18. Featured on the cover of Chemical Communications: P. Hendil-Forssell, M. Martinell, P.-O. Syrén*. Exploring water as building bricks in enzyme engineering. Chem. Commun. 2015, 51, 17221-17224.
  19. P.-O. Syrén*, S.C. Hammer, B. Claasen, B. Hauer. Entropy is Key to the Formation of Pentacyclic Terpenoids by Enzyme-Catalyzed Polycyclization. Angew. Chem. Int. Ed. 2014, 126, 4945-4949.
  20. P.-O. Syrén*, The solution to nitrogen inversion in amidases. FEBS J 2013, 280, 3069-3083.
  21. M. Seitz, P.-O. Syrén, L. Steiner, J. Klebensberger, B. Nestl, B. Hauer, Synthesis of heterocyclic terpenoids by promiscuous squalene-hopene cyclases. ChemBioChem 2013, 14, 436-439.
  22. S. C. Hammer#, P.-O. Syrén#, M. Seitz, B. Nestl, B. Hauer, Squalene hopene cyclases: highly promiscuous and evolvable catalysts for stereoselective C-C and C-X bond formation. Curr. Opin. Chem. Biol. 2013, 17, 293-300.
  23. P.-O. Syrén*, F. Le Joubioux, Y. Ben Henda, T. Maugard, K. Hult, M. Graber, Proton shuttle mechanism in the transition state of lipase catalyzed N-acylation of amino alcohols. ChemCatChem 2013, 5, 1842-1853.
  24. S. C. Hammer, J. Dominicus, P.-O. Syrén, B. Nestl, B. Hauer, Stereoselective Friedel–Crafts alkylation catalyzed by squalene hopene cyclases. Tetrahedron, 2012, 68, 7624-7629.
  25. P.-O. Syrén, P. Hendil-Forssell, L. Aumailley, W. Besenmatter, F. Gounine, A. Svendsen, M. Martinelle, K. Hult, Esterases with an introduced amidase-like hydrogen bond in transition state display increased amidase specificity. ChemBioChem 2012, 13, 645–648.
  26. P.-O. Syrén, K. Hult, Amidases have a hydrogen bond that facilitates nitrogen inversion but esterases have not. ChemCatChem 2011, 3, 853-860.
  27. K. Engström, M. Vallin, P.-O. Syrén, K. Hult, J.-E. Bäckvall, Mutated variant of Candida antarctica lipase B in (S)-selective dynamic kinetic resolution of secondary alcohols. Org. Biomol. Chem. 2011, 9, 81-82.
  28. P.-O. Syrén, K. Hult, Substrate Conformations Set the Rate of Enzymatic Acrylation by Lipases. ChemBioChem 2010, 11, 802 – 810.
  29. S. Marton, V. Léonard-Nevers, P.-O. Syrén, C. Bauer, S. Lamare, K. Hult, V. Tranc, M. Graber, Mutations in the stereospecificity pocket and at the entrance of the active site of Candida antarctica lipase B enhancing enzyme enantioselectivity. J. Mol. Catal. B: Enzym. 2010, 65, 11-17.
  30. P.-O. Syrén, E. Lindgren, H. W. Hoeffken, C. Branneby, S. Maurer, B. Hauer, K. Hult, Increased activity of enzymatic transacylation of acrylates through rational design of lipases. J. Mol. Catal. B: Enzym. 2010, 65, 3-10.
  31. M. Vallin, P.-O. Syrén, K. Hult, Mutant Lipase-Catalyzed Kinetic Resolution of Bulky Phenyl Alkyl sec-Alcohols: A Thermodynamic Analysis of Enantioselectivity. ChemBioChem 2010, 11, 411-416.
  32. P.-O. Syrén, A. Rozkov, S. R. Schmidt, P. Strömberg, Milligram scale parallel purification of plasmid DNA using anion-exchange membrane capsules and a multi-channel peristaltic pump. J. Chromatogr. B 2007, 856, 68-74.
  33. I. V. Pavlidis, N.M. Hendrikse, P.-O. Syrén*, Computational Techniques for Efficient Biocatalysis. Modern Biocatalysis: Advances Towards Synthetic Biological Systems. 2018, 5, 119-152 (Royal Society of Chemistry).
  34. P.-O. Syrén*, Understanding esterase and amidase reaction specificities by molecular modelling. Understanding enzymes; Function, Design, Engineering and Analysis. 2016, 15, 523-558 (PanStandford Publishing).